I will describe new methods for spatial transcriptomics and spacial genomics and contrast these methods with previous single cell and longitudinal genomics analysis approaches. I will focus first on methods for determining differential expression for spatial transcriptomic methods. I will then contract these early probabilistic methods with new methods built on variational auto encoders and generative ML approaches. Lastly I will describe bottlenecks, such as integrating imaging and genomic data in these studies. Prospects for building computational pipelines to integrate time, space and genomic coordinate will not be discussed, but will become apparent after deep reflection following the talk (but only if you pay attention).
Zoom: https://upenn.zoom.us/j/96846928909?pwd=Q3JPTTc5dURmQk5xL01OMjZUc2FXUT09
MathBio Seminar
Tuesday, March 9, 2021 - 4:00pm
Richard Bonneau
Flatiron Institute