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MathBio Seminar

Tuesday, February 2, 2021 - 4:00pm

Hye-Won Kang

University of Maryland Baltimore County


University of Pennsylvania

See Zoom link

Inherent fluctuations may play an important role in biochemical and biophysical systems when the system involves some species with low copy numbers. This talk will present the recent work on the stochastic modeling of reaction-diffusion processes in glucose metabolism. The first part of the talk introduces a compartment-based model for a simple glycolytic pathway using a continuous-time Markov jump process, which describes system features at different scales of interest. Then, we will see how the multiscale approximate method reduces the model complexity. We will briefly discuss how the compartment size in the spatial domain can affect the spatial patterns of the system.
In the second part of the talk, I will show another example for glucose metabolism where we see different-sized enzyme complexes. We hypothesized that the size of multienzyme complexes is related to their functional roles. We will see two models: one using a system of differential equations and the other using the Langevin dynamics.