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MathBio Seminar

Tuesday, November 30, 2021 - 4:00pm

Christopher Miles

UC Irvine


University of Pennsylvania

DRL 4C8 and via Zoom

For cells to divide, they must undergo the process of mitosis: the process of spatially organizing their copied genetic material to precise locations. Underlying molecular components harmonize to accomplish this task with puzzling speed and accuracy. To understand this, we propose viewing mitosis as a collective motion akin to schooling fish or insect swarms. I will discuss two related projects in this pursuit. The first is a classical modeling study, exploring how mutant cancer cells can mimic healthy cells in mitosis to avoid death. The second project focuses on incorporating 3D experimental spatial trajectories directly into the modeling process to learn unknown interactions. This work is with Alex Mogilner at NYU and Alexey Khodjakov of the NY State Department of Health.



Zoom link: