We study a generalization of Drinfeld modules arising from central division algebras over function fields, which we call Drinfeld-Stuhler modules. We prove some basic results about Drinfeld-Stuhler modules and their endomorphism rings, and then examine the existence and properties of Drinfeld-Stuhler modules with large endomorphism algebras, which are analogous to CM and supersingular Drinfeld modules. Finally, we examine the fields of moduli of Drinfeld-Stuhler modules.