Penn Arts & Sciences Logo

MathBio Seminar

Monday, March 28, 2016 - 4:00pm

James Greene

Rutgers University


University of Pennsylvania

318 Carolyn Lynch Lab

Resistance to chemotherapy is one of the major impediments to treatment success. Furthermore, experimental evidence suggests that drug resistance is a complex biological phenomena, with many influences that interact nonlinearly. In this talk, we present work on models of tumor heterogeneity and their impact on drug resistance. Specifically, we present a structured population model as a general framework for studying drug resistance, as well specific models of cell-cycle dynamics and its effect on cancer growth and treatment efficacy.